What diseases has Low Dose Naltrexone been useful for?
Bernard Bihari MD, as well as other physicians and researchers, have described beneficial effects of LDN on a variety of diseases.
Other Autoimmune Diseases:
LDN has demonstrated efficacy in thousands of cases.
Cancer. As of mid-2004, Dr. Bihari reported having treated over 300 patients who had a cancer that had failed to respond to standard treatments. Of that group, some 50%, after four to six months treatment with LDN, began to demonstrate a halt in cancer growth and, of those, over one-third have shown objective signs of tumor shrinkage.
Autoimmune diseases. Within the group of patients who presented with an autoimmune disease (see above list), none have failed to respond to LDN; all have experienced a halt in progression of their illness. In many patients there was a marked remission in signs and symptoms of the disease. The greatest number of patients within the autoimmune group are people with multiple sclerosis, of whom there were some 400 in Dr. Bihari's practice. Less than 1% of these patients has ever experienced a fresh attack of MS while they maintained their regular LDN nightly therapy.
HIV/AIDS. As of September 2003, Dr. Bihari had been treating 350 AIDS patients using LDN in conjunction with accepted AIDS therapies. Over the prior 7 years over 85% of these patients showed no detectable levels of the HIV virus — a much higher success rate than most current AIDS treatments, and with no significant side effects. It is also worth noting that many HIV/AIDS patients have been living symptom-free for years taking only LDN with no other medications.
Central Nervous System disorders. Anecdotal reports continue to be received concerning beneficial effects of LDN on the course of Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS—Lou Gehrig’s disease), and primary lateral sclerosis. Dr. Jaquelyn McCandless has found a very positive effect of LDN, in appropriately reduced dosage and applied as a transdermal cream, in children with autism.
How is it possible that one medication can impact such a wide range of disorders?
The disorders listed above all share a particular feature: in all of them, the immune system plays a central role. Low blood levels of endorphins are generally present, contributing to the disease-associated immune deficiencies.
Research by others — on neuropeptide receptors expressed by various human tumors — has found opioid receptors in many types of cancer:
Brain tumors (both astrocytoma and glioblastoma)
Head and neck squamous cell carcinoma
Lung cancer (both small cell and non-small cell)
Neuroblastoma and others...
These findings suggest the possibility for a beneficial LDN effect in a wide variety of common cancers.
Physicians and researchers have described beneficial effects of Low Dose Naltrexone (LDN) as an alternative treatment on a variety of autoimmune diseases, cancer and HIV/AIDS. From LDNResearchTrust.org
- Bladder Cancer
- Breast Cancer
- Colon & Rectal Cancer
- Liver Cancer
- Lung Cancer (Non-Small Cell)
- Lymphocytic Leukemia (chronic)
- Lymphoma (Hodgkin's and Non-Hodgkin's)
- Malignant Melanoma
- Multiple Myeloma
- Ovarian Cancer
- Pancreatic Cancer
- Prostate Cancer (untreated)
- Renal Cell Carcinoma
- Throat Cancer
- Uterine Cancer
Acute disseminated encephalomyelitis
Acute hemorrhagic leukoencephalitis
Amyotrophic Lateral Sclerosis
Autoimmune aplastic anemia
Autoimmune hemolytic anemia
Autoimmune inner ear disease
Autoimmune lymphoproliferative syndrome
Autoimmune peripheral neuropathy
Autoimmune polyendocrine syndrome
Autoimmune progesterone dermatitis
Autoimmune thrombocytopenic purpura
Balo disease/Balo concentric sclerosis
Chronic Fatigue Syndrome (CFS)
Chronic inflammatory demyelinating polyneuropathy
Chronic recurrent multifocal osteomyelitis
Chrons disease (CD / IBD)
Cold agglutinin disease
Complement component 2 deficiency
Crohns Disease (one of two types of idiopathic inflammatory bowel disease "IBD")
Cutaneous leukocytoclastic angiitis
Diabetes mellitus type 1
Diffuse cutaneous systemic sclerosis
Discoid lupus erythematosus
Epidermolysis bullosa acquisita
Essential mixed cryoglobulinemia
Fibrodysplasia ossificans progressiva
Giant cell arteritis
Guillain-Barré syndrome (GBS)
Hailey, Hailey Disease
Idiopathic Inflammatory Demyelinating Diseases
Idiopathic pulmonary fibrosis
Idiopathic thrombocytopenic purpura (See Autoimmune thrombocytopenic purpura)
Inclusion body myositis
Inflammatory demyelinating polyneuopathy
Juvenile idiopathic arthritis
Juvenile rheumatoid arthritis
Lambert-Eaton myasthenic syndrome
Linear IgA disease (LAD)
Lou Gehrig's disease (Also Amyotrophic lateral sclerosis)
Mixed Connective Tissue Disease
Multiple Sclerosis (MS)
Myalgic Encephalomyelitis (ME)
Neuromyelitis optica (Also Devic's Disease)
Occular cicatricial pemphigoid
Opsoclonus myoclonus syndrome
PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus)
Paraneoplastic cerebellar degeneration
Paroxysmal nocturnal hemoglobinuria (PNH)
Parry Romberg syndrome
Primary biliary cirrhosis
Primary sclerosing cholangitis
Progressive inflammatory neuropathy
Pure red cell aplasia
Restless leg syndrome
Stiff person syndrome
Subacute bacterial endocarditis (SBE)
Temporal arteritis (also known as ""giant cell arteritis"")
Ulcerative colitis (one of two types of idiopathic inflammatory bowel disease "IBD")
Undifferentiated connective tissue disease
LDN could help any condition where there is an Autoimmune Component.