What diseases has Low Dose Naltrexone been useful for?

Bernard Bihari MD, as well as other physicians and researchers, have described beneficial effects of LDN on a variety of diseases.

  • Bladder Cancer
  • Breast Cancer
  • Carcinoid
  • Colon & Rectal Cancer
  • Glioblastoma
  • Liver Cancer
  • Lung Cancer (Non-Small Cell)
  • Lymphocytic Leukemia (chronic)
  • Lymphoma (Hodgkin's and Non-Hodgkin's)
  • Malignant Melanoma
  • Multiple Myeloma
  • Neuroblastoma
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer (untreated)
  • Renal Cell Carcinoma
  • Throat Cancer
  • Uterine Cancer
Other Diseases
  • Common Colds (URI’s)
  • Emphysema (COPD)

  • ALS (Lou Gehrig's Disease)
  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Hereditary Spastic Paraparesis
  • Multiple Sclerosis (MS)
  • Parkinson's Disease
  • Primary Lateral Sclerosis (PLS)
  • Progressive Supranuclear Palsy
  • Transverse Myelitis

Other Autoimmune Diseases:
  • Ankylosing Spondylitis
  • Behcet's Disease
  • Celiac Disease
  • Chronic Fatigue Syndrome
  • CREST syndrome
  • Crohn's Disease
  • Dermatomyositis
  • Dystonia
  • Endometriosis
  • Fibromyalgia
  • Hashimoto’s Thyroiditis
  • Irritable Bowel Syndrome (IBS)
  • Myasthenia Gravis (MG)
  • Nephrotic Syndrome
  • Pemphigoid
  • Primary Biliary Cirrhosis
  • Psoriasis
  • Rheumatoid Arthritis
  • Sarcoidosis
  • Scleroderma
  • Sjogren’s Syndrome
  • Stiff Person Syndrome (SPS)
  • Systemic Lupus (SLE)
  • Ulcerative Colitis
  • Wegener's Granulomatosis

LDN has demonstrated efficacy in thousands of cases.

Cancer. As of mid-2004, Dr. Bihari reported having treated over 300 patients who had a cancer that had failed to respond to standard treatments. Of that group, some 50%, after four to six months treatment with LDN, began to demonstrate a halt in cancer growth and, of those, over one-third have shown objective signs of tumor shrinkage.

Autoimmune diseases. Within the group of patients who presented with an autoimmune disease (see above list), none have failed to respond to LDN; all have experienced a halt in progression of their illness. In many patients there was a marked remission in signs and symptoms of the disease. The greatest number of patients within the autoimmune group are people with multiple sclerosis, of whom there were some 400 in Dr. Bihari's practice. Less than 1% of these patients has ever experienced a fresh attack of MS while they maintained their regular LDN nightly therapy.

HIV/AIDS. As of September 2003, Dr. Bihari had been treating 350 AIDS patients using LDN in conjunction with accepted AIDS therapies. Over the prior 7 years over 85% of these patients showed no detectable levels of the HIV virus — a much higher success rate than most current AIDS treatments, and with no significant side effects. It is also worth noting that many HIV/AIDS patients have been living symptom-free for years taking only LDN with no other medications.

Central Nervous System disorders. Anecdotal reports continue to be received concerning beneficial effects of LDN on the course of Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS—Lou Gehrig’s disease), and primary lateral sclerosis. Dr. Jaquelyn McCandless has found a very positive effect of LDN, in appropriately reduced dosage and applied as a transdermal cream, in children with autism.

How is it possible that one medication can impact such a wide range of disorders?

The disorders listed above all share a particular feature: in all of them, the immune system plays a central role. Low blood levels of endorphins are generally present, contributing to the disease-associated immune deficiencies.

Research by others — on neuropeptide receptors expressed by various human tumors — has found opioid receptors in many types of cancer:

These findings suggest the possibility for a beneficial LDN effect in a wide variety of common cancers.

 Source: http://www.LowDoseNaltrexone.org


Physicians and researchers have described beneficial effects of Low Dose Naltrexone (LDN) as an alternative treatment on a variety of autoimmune diseases, cancer and HIV/AIDS. From LDNResearchTrust.org


Other Diseases

Acute disseminated encephalomyelitis
Acute hemorrhagic leukoencephalitis
Addison's Disease
Alopecia areata
Amyotrophic Lateral Sclerosis
Ankylosing Spondylitis
Anti-GBM/TBM Nephritis
Antiphospholipid syndrome
Antisynthetase syndrome
Atopic allergy
Atopic dermatitis
Autoimmune aplastic anemia
Autoimmune cardiomyopathy
Autoimmune enteropathy
Autoimmune hemolytic anemia
Autoimmune hepatitis
Autoimmune inner ear disease
Autoimmune lymphoproliferative syndrome
Autoimmune pancreatitis
Autoimmune peripheral neuropathy
Autoimmune polyendocrine syndrome
Autoimmune progesterone dermatitis
Autoimmune thrombocytopenic purpura
Autoimmune urticaria
Autoimmune uveitis
Balo disease/Balo concentric sclerosis
Bechets Syndrome
Berger's disease
Bickerstaff's encephalitis
Blau syndrome
Bullous pemphigoid
Castleman's disease
Celiac disease
Chronic Fatigue Syndrome (CFS)
Chronic inflammatory demyelinating polyneuropathy
Chronic recurrent multifocal osteomyelitis
Chrons disease (CD / IBD)
Churg-Strauss syndrome
Cicatricial pemphigoid
Cogan syndrome
Cold agglutinin disease
Complement component 2 deficiency
Cranial arteritis
CREST syndrome
Crohns Disease (one of two types of idiopathic inflammatory bowel disease "IBD")
Cushing's Syndrome
Cutaneous leukocytoclastic angiitis
Dego's disease
Dercum's disease
Dermatitis herpetiformis
Diabetes mellitus type 1
Diffuse cutaneous systemic sclerosis
Discoid lupus erythematosus
Dressler's syndrome
Enthesitis-related arthritis
Eosinophilic fasciitis
Eosinophilic gastroenteritis
Epidermolysis bullosa acquisita
Erythema nodosum
Essential mixed cryoglobulinemia
Evan's syndrome
Fibrodysplasia ossificans progressiva
Fibromyalgia (FB)
Fibrosing aveolitis
Gastrointestinal pemphigoid
Giant cell arteritis
Goodpasture's syndrome
Graves' disease
Guillain-Barré syndrome (GBS)
Haemolytic anaemia
Hailey, Hailey Disease
Hashimoto's encephalitis
Hashimoto's thyroiditis
Henoch-Schonlein purpura
Herpes gestationis
Idiopathic Inflammatory Demyelinating Diseases
Idiopathic pulmonary fibrosis
Idiopathic thrombocytopenic purpura (See Autoimmune thrombocytopenic purpura)
IgA nephropathy
Inclusion body myositis
Inflammatory demyelinating polyneuopathy
Interstitial cystitis
Juvenile idiopathic arthritis
Juvenile rheumatoid arthritis
Kawasaki's Disease
Lambert-Eaton myasthenic syndrome
Leukocytoclastic vasculitis
Lichen planus
Lichen sclerosus
Linear IgA disease (LAD)
Lou Gehrig's disease (Also Amyotrophic lateral sclerosis)
Lupoid hepatitis
Lupus erythematosus
Majeed syndrome
Ménière's disease
Microscopic polyangiitis
Miller-Fisher syndrome
Mixed Connective Tissue Disease
Mucha-Habermann disease
Multiple Sclerosis  (MS)
Myalgic Encephalomyelitis (ME)
Myasthenia gravis
Neuromyelitis optica (Also Devic's Disease)
Occular cicatricial pemphigoid
Opsoclonus myoclonus syndrome
Ord thyroiditis
Palindromic rheumatism
PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus)
Paraneoplastic cerebellar degeneration
Paroxysmal nocturnal hemoglobinuria (PNH)
Parry Romberg syndrome
Pars planitis
Parsonnage-Turner syndrome
Pemphigus vulgaris
Perivenous encephalomyelitis
Pernicious anaemia
POEMS syndrome
Polyarteritis nodosa
Polymyalgia rheumatica
Primary biliary cirrhosis
Primary sclerosing cholangitis
Progressive inflammatory neuropathy
Psoriatic arthritis
Pure red cell aplasia
Pyoderma gangrenosum
Rasmussen's encephalitis
Raynaud phenomenon
Reiter's syndrome
Relapsing polychondritis
Restless leg syndrome
Retroperitoneal fibrosis
Rheumatoid arthritis
Rheumatoid fever
Schmidt syndrome
Schnitzler syndrome
Sjögren's syndrome
Stiff person syndrome
Still's disease
Subacute bacterial endocarditis (SBE)
Susac's syndrome
Sweet's syndrome
Sydenham chorea
Sympathetic ophthalmia
Takayasu's arteritis
Temporal arteritis (also known as ""giant cell arteritis"")
Tolosa-Hunt syndrome
Transverse myelitis
Ulcerative colitis (one of two types of idiopathic inflammatory bowel disease "IBD")
Undifferentiated connective tissue disease
Undifferentiated spondyloarthropathy

LDN could help any condition where there is an Autoimmune Component.